CDH1 and cancer: Interestingly, an additional new metastatic cSCC cell line UW-CSCC3—which appears to have an intermediate EMT phenotype and expresses moderate levels of E-cadherin compared to UW-CSCC1 and UW-CSCC2 (Supplementary Figures S4 and S5)—forms an intermediate MCTS with DFs, with small fibroblast cores surrounded by loose cancer aggregates (Supplementary Figure S5).