As for tumor-prone sites, Xu et al. analyzed the data of 1361 patients with gastric cancer and found that, compared with other types of gastric cancer, gastric SRCC was located ore frequently in the middle and lower-1/3 region of the stomach, and the gastric antrum (including pylorus) was the most common site of SRCC (33.4%) [23], which may be closely related to the higher secretion of gastrin and hormone regulation. This evidence concerns the gene GAST and gastric cancer.