Key pathways affected by DEGs included cytochrome NOTCH signaling pathway, IL-17 signaling pathway, Herpes simplex virus 1 infection, Systemic lupus erythematosus, Asthma, Measles, Lysosome, TNF signaling pathway, T cell receptor signaling pathway, NOD-like receptor signaling pathway (Figure 4E). The gene discussed is TNF; the disease is systemic lupus erythematosus.