NOTCH3 and rheumatoid arthritis: Immunofluorescence experiments further showed that compared with the control group, NOTCH3 fluorescence intensity was significantly enhanced in the LPS group, and NOTCH3 gradually ablated after BbFH administration compared with the LPS group, which was able to inhibit LPS-induced expression of NOTCH3 in RA-RAW264.7 cells, suggesting that the mechanism of RA-RAW264.7 cells in NOTCH deserves further research (Figure 7I).