The combined polyphenolic treatment not only suppresses NF-κB activation and pro-inflammatory cytokine release in LPS-stimulated macrophages [63] but also promotes Nrf2/HO-1 pathway activation, as demonstrated in neuroprotective studies using the human neuroblastoma cell line (SH-SY5Y) [64], highlighting the multifaceted synergistic potential of these compounds. The gene discussed is HMOX1; the disease is neuroblastoma.