Furthermore, RAs could prevent inflammation-related neurodegenerative diseases by downregulating the NADPH oxidase 2–thioredoxin-interacting protein–nod-like receptor pyrin domain-containing protein 3 signaling axis, decreasing ROS production and inhibiting the secretion of inflammatory factors (interleukin-18 (IL-18) and interleukin-1 (IL-1)) in BV2 microglia in the brain [89]. This evidence concerns the gene IL18 and neurodegenerative disease.