EP300 and colorectal cancer: In addition, RAs have been shown to downregulate the expression of sirtuin 1(SIRT1) and upregulate the expression of the male absent on the first (MOF) and e1a-binding protein p300 (EP300) proteins, thereby affecting the acetylation levels of h4 (histone) and nuclear factor-κB (NF-κB) signaling pathway-related proteins (non-histone) in colorectal cancer, demonstrating their anti-colorectal cancer potential [75].