TAM1, 2, 3, 4, 7, and 8 have strong positive correlations not only with macrophages but also positively correlated with NK cells and CD8+ T cells, suggesting they may represent TAMs and their synergistic interactions with other immune cells, collectively shaping the immune microenvironment of renal cell carcinoma. Here, CD8A is linked to hereditary clear cell renal cell carcinoma.