While multiple animal models exist, usually based on introducing these highly penetrating mutations, sporadic ALS is very rare in the animal kingdom [14] except for degenerative myelopathy in dogs, yielding ALS-like symptoms, but which are also associated with SOD1 mutations (e.g. SOD1AE40K, [15]), but these mutations can be bred out, unlike human sporadic ALS. Here, SOD1 is linked to amyotrophic lateral sclerosis.