SLC16A1 and amyotrophic lateral sclerosis: Disruption of MCT1 in oligodendrocytes caused motor neuron toxicity, axonal damage and demyelination, in the motor cortex, but not other brain areas, of ALS patients showing a 50% decline in MCT1; MCT1 mRNA also declined in the spinal cord during the symptomatic stages in SOD1G93A mice [232].