LCN2 and metabolic syndrome: Conversely, ap2-promoter-driven LCN2 transgenic (Tg) mice and aged LCN2 Tg mice showed that overexpression of LCN2 in adipose tissue not only preserves adipose tissue function during aging but also promotes maintenance of glucose tolerance, decreases dyslipidemia, and prevents liver lipid accumulation and steatosis [64].