Of particular relevance, we identified ItgαE+CD8+, ItgαE−CD8+, CCR6+CD4+, and CCR6+Itgβ7−CD4+ T-cell subsets as positive correlates, and the ItgαE+CD4+ and ItgαE−CD4+ T-cell subsets as negative correlates of TPV values in crude models or upon adjustment for HIV (i.e., CD4 counts, CD8 counts, CD4/CD8 ratios, time on ART, time since infection) and CVD (i.e., D-dimers, smoking status, FRS) confounding factors. Here, CCR6 is linked to infection.