CD4 and HIV infectious disease: In addition to the expected depletion of TCRαβ+CD4+ T-cells and expansion of TCRαβ+CD8+ T-cells in the peripheral blood of PWH, these analyses reveal an altered composition of these circulating T-cell pools during ART-treated HIV-infection, with the abundance of subsets with a gut-homing/residency profile in HIV+ vs. HIV− participants.