Previously, it was shown that, high glucose inhibits Wilm’s tumor1 (WT1) and activates EZH2/β-catenin signaling pathway leading to podocytes injury in diabetic nephropathy [10], whereas Siddiqi et al. [17] have shown that EZH2 protects podocytes from oxidative stress and renal injury in diabetes [17]. This evidence concerns the gene EZH2 and diabetes mellitus.