Thakar et al. [66] also reported that in human umbilical vein endothelial cells (HUVECs), glucose fluctuation rather than stable high glucose levels induced EZH2 expression and H3K27me3, thus leading to Krueppel-like Factor 2 (KLF2) repression and endothelial inflammation in diabetes mellitus [66]. This evidence concerns the gene KLF2 and diabetes mellitus.