BLOC1S1 and endothelial dysfunction: A recent study by Dikalova et al. examining the pathogenic role of CypD acetylation in endothelial dysfunction and hypertension showed that the relative ratio of GCN5L1 to Sirt3 is a critical determinant of mitochondrial acetylation balance, where a 250% increase in GCN5L1/Sirt3 ratio promoted CypD acetylation, mitochondrial oxidative stress, and hypertension [69].