While some AML lines, such as HEL (Figure 6) and previously described Kasumi-1 and KG-1α [13], rely primarily on DGKα, others, such as HL-60 (Figure 5 and [16]) and the K562 subclone (Supplementary Figure S8) are DGKζ-dependent. The gene discussed is DGKA; the disease is acute myeloid leukemia.