Previous studies have shown that ritanserin downregulates key signaling molecules, including sphingosine kinase 1, JAK–STAT, MAPK, PARP, caspase-3, MCL1, and Bcl-xL in Kasumi-1 and KG-1α (AML) cell lines [13]. The gene discussed is SPHK1; the disease is acute myeloid leukemia.