In the analysis of the immune and metabolic profiles of GBM organoids from patient-derived glioblastoma stem cells (GBMS), an immune-like molecular program including cytokines, antigen presentation and processing, T cell receptor inhibitors, and interferon regulatory genes was found to be significantly related to HOPX+ and special AT-rich sequence-binding protein 2 (SATB2+) progenitor populations [85]. The gene discussed is HOPX; the disease is glioblastoma.