In conclusion, IL-8 chronic stimulus plays a role in the post-translational regulation of MMP9 and in the modulation of CXCR2 gene in HAOEC, and AAA patient’ serum acts more widely over expressed genes of the CXCR2/CXCL1/IL-8 axis, underlining the synergistic/antagonistic interplay among serum inflammatory mediators in affecting the vascular wall. The gene discussed is CXCL1; the disease is triple-A syndrome.