Quantitative data comparing survivin expression in drug-naïve and drug-resistant melanoma cells and PRI-724 effects obtained after 48 h of incubation are shown in Figure 6B. The results indicated that vemurafenib-resistant melanoma cells exhibited the highest expression of survivin among untreated cells, and these cells were the least responsive to PRI-724 at 0.63 μM. Here, BIRC5 is linked to melanoma.