To explore the potential association between CBP/β-catenin signaling and melanoma drug resistance, the GeneCards website (https://www.genecards.org/) was used to extract gene lists related to the keywords ‘CREBBP-dependent genes’, ‘CTNNB1-dependent genes’ and ‘melanoma drug resistance genes’, giving 1006, 1020, and 1431 genes, respectively (relevance score ≥ 10.00). This evidence concerns the gene CTNNB1 and melanoma.