Similarly, PRI-724 treatment resulted in downregulation of cyclin D1 in osteosarcoma cells, SARS-CoV-2-infected lung adenocarcinoma cells, and acute myeloid leukemia cells, as reported by Fang et al. [35], Kelch et al. [39], and Jiang et al. [41], respectively. This evidence concerns the gene CCND1 and osteosarcoma.