TNC, an extracellular matrix component often considered a potential biomarker for cancer-associated fibroblasts, has been shown upon knockdown to effectively inhibit glucose uptake, lactate production, and the expression of key glycolytic enzymes in prostate cancer cells; clinical data analysis further confirms that TNC is significantly associated with poor prognosis in prostate cancer patients [29]. Here, HK1 is linked to Familial prostate cancer.