For example, Hederacoside A, an oleanane-type saponin extracted from Anemone raddeana roots, induces proteasome-mediated degradation and inhibits the transcriptional activity of both full-length and splice variant AR, thereby suppressing prostate cancer cell growth; moreover, its combination with the chemotherapeutic drug docetaxel enhances therapeutic efficacy [40]. Here, AR is linked to Familial prostate cancer.