IKBKB and glioblastoma: Experiments conducted by Zhang and coworkers achieved the desired M2→M1 reprogramming in both peripheral as well GBM TME macrophages by deploying in vitro-transcribed (IVT) mRNA for Interferon Regulatory Factor 5 (IF5) and inhibitor of nuclear factor kappa-B kinase subunit beta (IKKβ) encapsulated in biodegradable polymeric nanoparticles (NP) in an injectable formulation [9].