To further corroborate the transcriptional regulatory role of the CoREST complex on NOLC1, we cloned the promoter of NOLC1 in the pGL4.10 plasmid and performed a promoter–reporter assay in two melanoma cell lines, A375 and WM983B, with and without the CoREST complex inhibitor, Corin. The gene discussed is RCOR1; the disease is melanoma.