KLRK1 and urinary bladder carcinoma: Conversely, Huyan et al. [54] showed that miR-186-5p released by bladder cancer cells in tumor-derived EVs, impairs NK cell cytotoxicity by directly targeting DAP10, which encodes for an adapter of NKG2D, leading to its downregulation and an overall immunosuppressive, pro-tumoral phenotype.