Ashiru et al., through a series of elegant experiments, showed that MICA*008, the most frequently expressed allele of MICA, and a ligand of NKG2D, is released by cervical cancer cells in exosomes (differently from other alleles that are shed as soluble proteins), and by binding to NKG2D on the surface of NK cells, exosomal MICA*008 induces downregulation of NKG2D from the surface of NK cells and causes a significant loss of their cytotoxic activity, representing a new strategy of exosome-mediated immune-escape mechanism [51]. The gene discussed is MICA; the disease is cervical cancer.