IL2 and cancer: In their work, Dosil et al. investigated the effects of NK-EVs on T-cell anti-cancer responses and identified a signature of NK vesicular miRs (namely, miR-10b-5p, -92a-3p, and -155-5p) and isomiRs (miR isoforms that differ from the canonical miR sequence due to variations such as 5′- or 3′-end modifications, nucleotide additions/substitutions) promoting Th1 polarization and IFNγ and IL-2 production [57].