Moreover, in the KEGG and RCTM pathways (Figure 10D,E), autophagy, PINK1-PARKIN-mediated mitophagy, and NF-κB signaling dominated, with PD-1 checkpoint pathways as well as other significant pathways and their overlap genes (Table 2) suggesting immune–infertility crosstalk. The gene discussed is PRKN; the disease is Infertility.