Aqueous-soluble components of sporoderm-removed Ganoderma lucidum spore powder (A-GSP) were also reported to promote ferroptosis in OSCC by inducing Fe2+ influx, depleting GSH, upregulating ACSL4, and downregulating GPX4, resulting in mitochondrial dysfunction and tumor suppression in xenograft models [126]. This evidence concerns the gene GPX4 and neoplasm.