Notably, though NLRP3 induces the process of EndMT in SSc extra-cardiac tissues such as the lung and kidney [14,36], we have shown that a similar pathogenic mechanism is active at the cardiac level, thus suggesting that NLRP3-mediated EndMT represents an early and potentially initiating event in myocardial fibrotic transformation. The gene discussed is NLRP3; the disease is systemic sclerosis.