This is a short review and a comment and discussion of the recent publication entitled “BID Protein: A Participant in the Apoptotic Network with Roles in Viral Infections” by Wyżewski Z. et al. [30], These authors minimize the role of the activation platform formed by cardiolipin/Caspase-8/Bid in favor of the MCTH2 protein, but it is likely to be the other way around. This evidence concerns the gene BID and viral infectious disease.