Genes involved in innate immune responses, such as CASP8, INPP5D, ELMO1, FYN, SEMA6D, PDGFRB, MAP3K13, and ADAM10, and genes involved in immune regulation, such as FYN, CASP8, INPP5D, RCAN3, IFNGR2, FCER1G, and MAP3K13, were identified among the differentially methylated genes with the highest fold-change in COVID-19 patients. The gene discussed is INPP5D; the disease is COVID-19.