The hypermethylated genes with the lowest p values for hospitalized COVID-19 patients at inclusion (T1) vs. at 6 weeks post-inclusion (T2) were PARP9, ABCA1, MX1, OAS1, ARID5B, and the hypomethylated genes included TMEM131, ROCK1, IFNGR1, CFAP61, VRK2, and C6orf138 (Figure 4D). The gene discussed is VRK2; the disease is COVID-19.