The hypermethylated genes with lowest p-values for hospitalized COVID-19 patients at inclusion (T1) and at 6 weeks post-inclusion (T2) versus HCs included NXN, SLC2A12, RAD54L2, GIMAP5, and PPP2R5C, while the top five hypomethylated genes with lowest p-value were, LOC101928650, DLX5. This evidence concerns the gene DLX5 and COVID-19.