ROBO1 and osteosarcoma: For instance, the Slit2/Robo1 axis has been linked to cancer proliferation via the Warburg effect in osteosarcoma [20], and it induces epithelial–mesenchymal transition (EMT) in colorectal epithelial cells [21] by associating Src and E-cadherin with the Robo1 cytoplasmic domain.