As shown in the mechanistic network of Figure 3D, CTSB, together with another 84 proteins, is mainly related to the modulation of “binding of tumor cell lines” (p-value = 1.06 × 10−17), demonstrating that protein cargoes of AML-derived EVs are fundamental for tumor progression, since increased levels of CTSB circled in the network correlate with the metastatic process. This evidence concerns the gene CTSB and neoplasm.