CTSD and CTSB were predicted as significant Upstream Regulators for all three investigated AML-EVs by the same protein dataset, as described in the functional network of Figure 3E (CTSB: EVs HL-60 p-value = 9.84 × 10−3, EVs OCI-AML-2 p-value = 4.54 × 10−3, EVs OCI-AML-3 p-value = 4.84 × 10−3; CTSD: EVs HL-60 p-value = 1.66 × 10−5, EVs OCI-AML-2 p-value = 3.39 × 10−5, EVs OCI-AML-3 p-value = 3.58 × 10−5). This evidence concerns the gene CTSB and acute myeloid leukemia.