PKLR and acute myeloid leukemia: Among proteins identified as commonly expressed in EVs from all three AML cell lines, pyruvate kinase 1/2 (PMK1/2) was significantly higher in OCI-AML-2 and OCI-AML-3 than in HL-60, as shown in Figure 3A, where the relative abundance of the protein was measured as an iBAQ average of the analytical triplicate for each EVs sample.