TNFSF11 and osteoporosis: To our knowledge, the RANKL/OPG ratio is still not used in the routine laboratory for the diagnosis of osteoporosis in addition to the standard parameters of bone remodeling such as bone-specific alkaline phosphatase, osteocalcin, N-terminal pro-peptide of type I procollagen (PINP), N-telopeptide (NTX), C-telopeptide (CTX), and pyridinoline crosslinks [116].