It is noteworthy that double-mutant mice homozygous for MYOCY437H and heterozygous for a mutated form of the antioxidant enzyme superoxide dismutase 2 exhibit earlier and more severe IOP elevation, as well as more dramatic RGC degeneration compared to mice expressing MYOCY437H alone [77], supporting the hypothesis of an involvement of oxidative stress in the pathogenesis of MYOC-associated glaucoma. Here, MYOC is linked to glaucoma.