CD274 and neoplasm: While the mechanisms of ICI cardiotoxicity are not completely understood, several theories have emerged: cross-reactivity between myocardial cells and tumor cells, tumor cell death releasing intracellular antigens, activation of dormant self-reacting T-cell clones and overexpressed PD-L1 in ischemic myocardium all leading to T-cell infiltration coupled with direct cytotoxic injury and increased levels of pro-inflammatory cytokines [36,37].