GLP1R and type 2 diabetes mellitus: Furthermore, patients with T2DM who follow a CR program require a patient-centered approach that includes risk stratification, setting individual blood glucose targets, administering medication with proven protective effects (iSGLT2, GLP-1 receptor agonists, metformin), modulation of cardio-metabolic risk, prevention & frequent screening of potential complications, and frequent monitoring (Table 4).