A pivotal study further clarified the dynamics of IL-6 in AIS, revealing that while elevated IL-6 levels at stroke onset may sometimes reflect underlying or undiagnosed comorbidities, a consistent rise in IL-6 within the first 24 h post-onset—observed in approximately 90% of AIS patients—strongly support stroke as the primary trigger for this acute inflammatory response [62]. The gene discussed is IL6; the disease is stroke disorder.