Our study findings are in contrast to a previously published study in 2014 which reported a higher incidence of the composite outcome of markers of placental dysfunction, which included preeclampsia, SGA, stillbirth or placental abruption, and birth before 30 weeks following a third-trimester drop in total IR (defined as ≥15% from the highest insulin dose to the lowest), and when compared with those that did not experience a third-trimester drop in IR. The gene discussed is INS; the disease is preeclampsia.