Individuals with low IC presented hyperglycemia, high levels of inflammatory markers such as interlekin-6 (IL-6), plasma C-reactive protein (CRP), monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor receptor-1 (TNFR-1), growth differentiation factor-15 (GDF-15), and low serum levels of dehydroepiandrosterone sulfate (DHEA-S) [76]. The gene discussed is GDF15; the disease is Hyperglycemia.