We envision a concise, procedure-specific PRS risk tool organized in three layers for non-trivial surgical cases: (1) universal core (Hb/HCT, platelets, WBC, creatinine, coagulation assay), (2) condition-triggered tests (e.g., HbA1c for diabetes, CRP when infection suspected), and (3) risk- or procedure-specific add-ons (e.g., albumin for bariatric or oncologic cases; electrolytes in burn or fluid-shift). Here, GSTM1 is linked to diabetes mellitus.