KRT18 and liver disorder: Additional information regarding liver health status was obtained by detection of markers of liver disease in stored plasma samples [23] such as hyaluronic acid (HA)—the main component of ECM produced by fibroblasts and specialized connective tissue cells [24], and cytokeratin 18 (CK18) fragment M30 (CK18-M30), which increases in sera after caspase-cleaved hepatocyte apoptosis [25].