TP53 and lung adenocarcinoma: Some inhibitors are universal and affect every subtype of lung adenocarcinoma with hypoxia presence: PX-478 inhibits HIF-1α translation by blocking its interaction with the ribosome and also increases p53 and reduces c-Myc translation; and EZN-2968 targets HIF-1α mRNA, leading to decreased HIF-1 protein levels [18,19].