Biomarker potential: miR-423-5p demonstrates significant diagnostic efficacy; an 8-miRNA panel enhances accuracy when used in conjunction with NT-proBNP; miR-21 aids in diagnosis and prognosis while predicting the onset of HFpEF in older hypertensive patients; miR-132 sharpens the assessment of rehospitalization risk; miR-145 is diminished in acute myocardial infarction and heart failure, tracking injury; miR-150-5p is reduced in advanced heart failure; and miR-210-3p contributes value within a multimarker approach (alongside NT-proBNP, sST2, and galectin-3). Here, NPPB is linked to acute myocardial infarction.