GJA1 and cardiac arrhythmia: Numerous investigations have utilized in vivo models involving mice or rats to examine the regulatory effects of miRNAs such as miR-1, miR-130a, miR-206, miR-27b, and novel-miR-17 on arrhythmia through the downregulation of critical proteins including Cx43, Kir2.1, Gja1, and CACNA2D2.