To examine these hypotheses, we performed pY-STAT3 IHC staining of sections of Swiss-rolled colons from vehicle- and TTI-101-treated AOM-DSS mice; digital image analysis was used to assess levels of nuclear pY-STAT3 within the epithelial and stromal cells of normal vs. dysplastic colonic mucosa (Figure 3). This evidence concerns the gene STAT3 and infectious otitis media.