Of the 23 downregulated genes (genes decreased by the addition of DSS to AOM that were increased by TTI-101 treatment), IPA revealed that these genes were not linked with CRC pathogenesis or needed hypermethylation to exert a role in CRC pathogenesis, including the top 10 genes that underwent the greatest change: LEP [39], RASGRF1 [40], Best4-ps [41], NSUN7 [42], OAZ3 [43], Maskbp3 [44], KCNS1 [45], LINGO1 [46], FLRT1 [47], and DNAH14 [48]. This evidence concerns the gene LEP and infectious otitis media.