To examine the effect of TTI-101 on the colon transcriptome of AOM-DSS mice and to identify STAT3 gene targets that may mediate TTI-101′s ability to reduce adenomas, we performed transcriptome analyses on mouse colons from three groups—mice given AOM alone (Sham), vehicle-treated AOM-DSS mice (Vehicle), and TTI-101-treated AOM-DSS mice (TTI-101). The gene discussed is STAT3; the disease is infectious otitis media.