Taken together, the transcriptomic results indicate that there is a marked anti-oncogenic effect of TTI-101 on the CRC transcriptome mediated largely by its targeting of STAT3 and STAT1 in the colons of TTI-101-treated AOM-DSS mice, which helps to explain its ability to reduce colon adenomas (Figure 2). Here, STAT3 is linked to infectious otitis media.