Figure 3h and Figure S18 show that the serum interleukin-6 (IL-6) content of mice in the BC@COF-TB group was significantly lower than that in the LPS group, and the anti-inflammatory effect of the free drug and single drug-loaded COF was lower than that of double drug-loaded COF, indicating that the double drug-loaded COF had a good anti-inflammatory effect. The body weight changes in mice were continuously detected during the establishment of the inflammation model and treatment (Figure 3i). This evidence concerns the gene IL6 and tuberculosis.