Improved cardiac function in diabetic cardiomyopathy: EGCG enhanced LV function and reduced fibrosis in diabetic rats. Mechanistically, benefits were linked to autophagy activation (AMPK/mTOR) and suppression of TGF-β-mediated fibrosis, highlighting a novel cardioprotective pathway. The gene discussed is PRKAA2; the disease is diabetic cardiomyopathy.