The miR-125 family also regulates immune function; experimental gain of miR-125b-5p enhances IFN-γ+ CD8+ T cells and limits Tregs, implying that loss of miR-125b undermines interferon-driven cytotoxicity (with supportive HNSCC tumor-suppressor evidence for miR-125b-1 loss) [32]. Here, CD8A is linked to neoplasm.