HPSE and neoplasm: In this platelet state primed for tumor binding, vascular adhesion, and metastatic assistance, central platelet subnetworks involve the ITAM-SYK hyperactivation core (FCGR2A, SYK, GRB2) with JAK2, CAMK1, and PTK2 as potential intervention points; a cytoskeleton/adhesion sub-module (ITGA2B, FLNA, MYL9, and DOCK1), an ECM-remodeling/metalloprotease axis (MMP1, HPSE), and an apoptosis sub-module centered around CASP3.