Piperlongumine rapidly decreased cellular Myelocytomatosis oncogene (c-Myc) expression in pancreatic cancer cells (Panc1), a process associated with ROS-dependent downregulation of miR-27a and miR-17/20a and upregulation of the transcription factors: zinc finger and BTB domain containing 10/4 (ZBTB10, ZBTB4). Here, ZBTB10 is linked to pancreatic neoplasm.