The let-7 family, commonly linked to tumor suppression, influences a broad spectrum of cellular pathways through the regulation of various genes (BTG2, vesicular, integral membrane protein 1, VSNL1; mitogen-activated protein kinase kinase kinase 4, MAP4K4; solute carrier family 35 member D2, SLC35D2; chromodomain helicase DNA binding protein 7, CHD7; Fraser Syndrome 1, FRAS1; ephrin receptor A4, EPHA4; phosphoglucomutase 2 like 1, PGM2L1). The gene discussed is MAP4K4; the disease is neoplasm.