Elevated antibody titers against transaldolase have been reported by Western blot in both serum and CSF of a subset of MS patients (25/87), whereas such reactivity was absent in OND patients (in both CSF and serum) and in other autoimmune diseases, with only a single case of essential cryoglobulinemia testing positive in serum [109]. The gene discussed is TALDO1; the disease is cryoglobulinemia.