However, As2O3-NPs decrease the expression of the proteins, Dnmt3a (DNA(cytosine-S)-methyltransferase-3α), Dnmt3b (DNA(cytosine-S)-methyltransferase-3β), and Dnmt1 (DNA(cytosine-S)-methyltransferase-1), but inhibit tumour growth more strongly than As2O3, probably due to the downregulation of PCNA (proliferating cell nuclear antigen) and DNMT-related proteins and the upregulation of GSDME-N (Gasdermin E-N) [406]. This evidence concerns the gene PCNA and neoplasm.