Since hnRNP-A3 is also expressed in PBMCs, we evaluated hnRNP-A3 levels in PBMCs from adult-onset DM1 patients and found a reduction in hnRNP-A3 in DM1 patients carrying more than 100 CTG repeats (Figure 5D). Here, HNRNPA3 is linked to myotonic dystrophy type 1.