Markedly, enriched pathways included MeCP2 and its related disorders (p-value = 8.59 × 10−5), TGF-β signaling (p-value = 2.64 × 10−5), pluripotency regulation (p-value = 4.10 × 10−12), actin cytoskeleton dynamics (p-value = 5.11 × 10−7), calcium signaling (p-value = 2.07 × 10−5), one-carbon metabolism (p-value = 7.42 × 10−4), IL-6 signaling (p-value = 5.08 × 10−5), and IL-17A signaling (p-value = 4.01 × 10−4) in 1 month Abca4-/- versus wild-type RPE (Figure 1D,E), all previously linked to neurodegenerative diseases and dysfunction of RPE in AMD [46,47,48,49,50,51]. Here, ABCA4 is linked to age-related macular degeneration.