On a functional level, MeCP2 binds to the Transforming Growth Factor-beta (TGF-β) gene promoter in RPE cells [36,37] and regulates epithelial–mesenchymal transition (EMT) [38,39], a key pathogenic mechanism linked to age-related macular degeneration (AMD) [40]. This evidence concerns the gene TGFB1 and age-related macular degeneration.