The synthesis is narrative in nature, without systematic or quantitative analysis, and was developed through a comprehensive literature search of PubMed/MEDLINE, Scopus, and Web of Science databases for English-language articles published between 2010 and 2025 using combinations of the following keywords: “lipedema,” “tirzepatide,” “GLP-1,” “GIP,” “fibrosis,” and “adipose tissue”. The gene discussed is GIP; the disease is Lipedema.