UCP1 and Lipedema: Beyond weight loss, preclinical and clinical studies have documented anti-inflammatory, antifibrotic, and adipose remodeling properties, including increased Uncoupling Protein-1 (UCP1) mediated thermogenesis through activation of beige adipocytes and restoration of mitochondrial efficiency., which directly overlap with lipedema’s pathogenic mechanisms [21,24,25,26,27,28].