For instance, according to the research conducted by Dadkhah et al. [159] Fluoxetine-loaded pegylated chitosan nanoparticles significantly enhanced the neuroprotective effects in a rat model of hippocampal demyelination, improving memory function, reducing anxiety-like behaviors, increasing Brain-Derived Neurotrophic Factor (BDNF) levels in the hippocampus, and more effectively reducing demyelination lesions compared to fluoxetine alone. Here, BDNF is linked to Anxiety.