CFLAR and triple-negative breast carcinoma: For example, tetrahydrocurcumin (THC), a gut microbiota-derived major metabolite of curcumin, has shown enhanced anti-inflammatory and antioxidant activity compared to curcumin, and was also found to inhibit the TRIP13/USP7/c-FLIP interaction in triple-negative breast cancer cells, promoting apoptotic signaling [46,47].